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Approximately98% of the T cells undergo this apoptosis and are thenphagocytosed by the macrophages.
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Although early studies for the detection of p63did not differentiate among different isoforms, recent studies used isoform-speci? cRT-PCR coupled with Western blot analysis to quantitatively demonstrate that?Np63? is the predominant p63 isoform expressed in squamous cell carcinomas.Using such an approach, it has been reported that tumor-suppressive TAp63 overex-pression is rare in HNSCC, and that ?Np63 mRNA expression was at least 100-foldmore abundant than TAp63 mRNA in all cases [ 87 , 100 ]. Sideroblastic anaemia associated withisoniazid and pyrazinamide (which interfere with pyridoxinemetabolism and action) therapy needs to be treated withpyridoxine.